Thursday, February 28, 2013

Blog 5: Affordable and portable disease diagnostics


            Many third world countries have many diseases that thrive because they do not have the means to diagnose, treat, and manage them. Therefore, for the people that has these diseases and do not know it, will spread it without knowing it, which causes a huge outbreak. Now, thanks to a team of Caltech engineers and biologists, an inexpensive, portable, easy-to-use device, is said to speed the diagnosis of HIV/AIDS and other diseases. This device is also said to improve treatment in all areas over the world. What these biologists and engineers have done is built a new polymerase chain reaction (PCR) device. The machine is small enough to fit into a backpack and is simple to operate. They compare it to the simplicity of using a DVD player. What the machine does is generate many copies of a pathogenic nucleic acid, which allows the infection to be detected.
            This device was the result of 10 years of research. When H5N1 bird flu pandemic happened in Asia, this was when the device first was put to use. Small amounts of the viral material were taken and a large number of copies were made so the virus could be identified. The initial cost of the PCR machine, in 2005, was $50,000. Since this is obviously too expensive for developing countries, a far less expensive PCR machine was created but it did not give results fast enough. Researchers then teamed up with another scientist, Baltimore, who is one of the world’s leading experts on AIDS and won his Nobel for work in virology. They thought that if they could build something that was useful for detecting H5N1, then it would be equally useful in detecting other viruses or diseases like HIV/AIDS. By the end of 2006, a newer version of the machine was capable of evaluating a sample in 94 seconds compared to 45 minutes like the previous machines. This machine was fast and relatively cheap, $13,000, but was still the size of a microwave oven. The newest machine, the one talked about in the previous paragraph, runs off a rechargeable battery and operates from the push of a button. It can diagnose acute lower-respiratory diseases, diarrheal diseases, malaria, and other such conditions. The goal is to bring the cost of the machine below $1,000 and each test under $5.

2/28/13
1:44 PM

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