“Anti-H.I.V. Trial in Africa Canceled Over Failure to Prevent Infection” by Donald G. McNeil Jr.
-Amber Kocher
A trial in Africa that was trying to prevent HIV infections in women was cancelled due to failure. This study was a trial of a microbicide gel that women used vaginally to protect them against the virus, but still allowed them to get pregnant. This trial was the second one, and it succeeded what was reported as a successful first trial. Researchers were disappointed in this trials failure because of the good results they had from the first one. This gel was being developed so that women who feared rejection and violence from there partners (if asked to use a condom) could use it secretly. The original study showed that it “protected 39% of the women who used it and that those who used it most regularly reduced their chances of infection by 54%”. The second trial was cancelled because it showed that the drug was safe but it was not effective, and it ethically required the cancellation to prevent any further infections in the trial patients. Data and answers for why the trial failed will not be clear until 2012 because the trial is still blind and the placebo and actual drug patients won’t be revealed until that time.
This failure of this trial is hard hitting because researchers and organizations are working on things like this to help solve social and health problems in places like Africa where the people don’t have access to proper health care and treatment. HIV and AIDS is such a huge problem in the world, and its extremely concentrated in the continent of Africa, so this study failing is quite a setback. The development of the microbicide gel is a good step in the right direction, and hopefully the research and the data will unveil what went wrong, and researchers will be able to perfect it and try again. With cultures and practices being different, and condoms and birth control not always an option, developing something that these women can use safely and effectively is something that needs to continue to have attention.
http://www.nytimes.com/2011/11/26/health/research/anti-hiv-gel-trial-is-canceled-in-africa.html?ref=health